View the San Francisco 49ers vs. Houston Texans game played on October 26, 2025. Box score, stats, odds, highlights, play-by-play, social & more

The key is Jones beating the pass rush. The Houston defense is built around its front four getting pressure. Take that away and the 49ers can build long sustained drives and convert in the red zone against this defense. McCaffrey should have success on the ground, but could be limited in the air.

Kickoff from NRG Stadium is set for 1 p.m. ET, and the Texans are 2.5-point favorites, according to the latest 49ers vs. Texans odds. The over/under for total points scored is 42. The Texans are -151 money line favorites (risk $151 to win $100),

Houston Texans kicker Ka'imi Fairbairn's 33-yard field goal attempt is good against the the San Francisco 49ers.

Take a look at the injury report for the San Francisco 49ers (5-2), which has 16 players listed (including Christian McCaffrey), as the 49ers prepare for their matchup versus the Houston Texans (2-4) at NRG Stadium, on Sunday, Oct. 26 at 1 p.m. ET.

If the 49ers win Sunday in Houston, they’ll match their overall win total from last season and they’ll be alone atop the NFC West at 6-2.

Quarterback Brock Purdy will miss his fourth straight game for the San Francisco 49ers because of a toe injury

In what has been an unfortunate recurring theme, the San Francisco 49ers ’ Week 8 injury report is once again filled to the brim. Although not as full as it once was, Kyle Shanahan’s team will still be without Brock Purdy and Ricky Pearsall for their matchup with the Houston Texans.