The Wildcats desperately need to get back on track against the Buffaloes. Here's three guys to pay attention to on offense this Saturday.

On Wednesday night, the Big 12 released its first availability reports for this week’s games, and for Colorado it includes starting left guard Xavier Hill listed as out.

Pick OU: Under (53.5) Arizona has covered the spread three times in six games. Arizona is unbeaten ATS (2-0) as a 4.5-point favorite or greater this season. Out of six Arizona games so far this season, three have gone over the total. Colorado's record against the spread in 2025 is 4-4-0.

Find single game tickets to the Arizona Wildcats vs. Colorado Buffaloes college football Week 10 matchup on Saturday, November 1, 2025 at Folsom Field.

Arizona boasts the seventh-ranked defense in the Big 12, holding opponents to minimal yardage by meeting them behind the line of scrimmage. It is Arizona's aggressive defense that has the Wildcats tied for 14th in the FBS in tackles for loss.