Cytochrome P450 enzymes constitute a highly diverse superfamily that is pivotal in the metabolism of endogenous and exogenous compounds. In the context of cancer research, members such as CYP1B1 and ...
Cytochrome P450 enzymes constitute a vast and diverse superfamily of haem‐containing proteins that orchestrate a broad array of oxidative reactions. Their inherent versatility enables them to catalyse ...
Cytochrome P450 enzymes play an important role in the detoxification of pharmaceutical drugs and other foreign compounds. However, inherited genetic mutations can make certain P450 enzymes less ...
Laboratory automation and artificial intelligence. Image by EasyLabAuto - Own work, CC BY-SA 4.0. Laboratory automation and artificial intelligence. Image by EasyLabAuto - Own work, CC BY-SA 4.0. In a ...
To boost the statistical power to find Alzheimer’s genes, geneticists often use endophenotypes—measurable characteristics of the disease—in place of clinical diagnoses. Case in point: A genome-wide ...
For over 350 years, quinine and other extracts from the cinchona tree (Cinchona spp.) were the only effective medicines ...
Using directed evolution, researchers have developed an enzyme that catalyses the formation of biaryl bonds (Nature 2022, DOI: 10.1038/s41586-021-04365-7). This new enzyme makes carbon-carbon bonds ...
An interdisciplinary research team has successfully developed an innovative inhibitor that shows promise in fighting obesity and potentially preventing heart disease. The team developed an ...
M. Ekroos and T. Sjögren, "Structural basis for ligand promiscuity in cytochrome P450 3A4," Proc Natl Acad Sci, 103:13682-7, 2006. (Cited in 78 papers) Researchers at AstraZeneca in MöIndal, Sweden, ...
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