Proceedings of the National Academy of Sciences of the United States of America, Vol. 118, No. 28 (July 13, 2021), pp. 1-10 (10 pages) The evolutionary expansion of G protein-coupled receptors (GPCRs) ...

Scientists reveal how G protein-coupled receptors, major therapeutic drug targets, decode critical properties of their ligands. Through an international collaboration, scientists at St. Jude ...

G protein-coupled receptors (GPCRs) are expressed on the surface of cells and regulate a range of important functions. Because they are involved in so many sensory and physiological processes, ...

G-protein-coupled receptors (GPCRs) are among the most successful targets for drug discovery research. They represent the largest family of cell surface receptors with approximately 400 in the ...

Septerna's Native Complex platform isolates GPCRs in their native form, enabling advanced drug discovery for previously undruggable targets, including oral small-molecule therapeutics. Lead molecule ...

Calcium-sensing receptors (CaSRs), widely distributed in tissues and organs such as parathyroid glands, intestines, bones and kidneys, senses the concentration of calcium ions in the blood and ...

Announcing a new publication for Acta Materia Medica journal. G protein-coupled receptors (GPCRs) are important, potential drug targets for the treatment of metabolic disorders, such as obesity. GPCRs ...

SOUTH SAN FRANCISCO, Calif.--(BUSINESS WIRE)--Septerna, a clinical-stage biotechnology company pioneering a new era of GPCR-targeted drug discovery, today announced the dosing of the first ...