DNA damage tolerance (DDT), activated by replication stress during genome replication, is mediated by translesion synthesis and homologous recombination (HR). Here we uncover that DDK kinase, ...

At the scale of individual cells, the human body is constantly in motion. Every second, millions of cells divide, ...

When cells proliferate, genomic DNA is precisely duplicated once per cell cycle. Abnormalities in this DNA replication process can cause alterations in genomic DNA, promoting cellular aging, cancer, ...

For decades, the hunt for the genetic roots of common disease has focused overwhelmingly on single-letter changes in the DNA ...

Biological evolution is recorded in the genomeThe history of life deciphered from DNAAn organism's genome contains not only the information needed to build its current body, but also the remnants of ...

Why do human brains vary in size and shape, and how did our brains expand over evolutionary time to give us our enhanced ...

The MCM helicase is broadly bound across the genome, and its phosphorylation is antagonistically regulated by the kinase DDK and the phosphatase RIF1–PP1. TRESLIN–MTBP recognises the phosphorylated ...