Protein trafficking is a fundamental cellular process that ensures efficient sorting, modification, and delivery of proteins to their correct subcellular destinations. At its core, this process ...

Adaptor protein (AP) complexes play central roles in intracellular vesicular trafficking by coupling cargo selection to ...

Membrane trafficking is a fundamental cellular process that ensures the accurate delivery of proteins and lipids between distinct intracellular compartments. Central to this process are the Rab ...

Intracellular protein trafficking and secretion of proteins into the extracellular environment are sequential and tightly regulated processes in eukaryotic cells. Conventionally, proteins that are ...

Endocytosis is an important cellular process through which cells internalize substances such as water and nutrients. These substances are first transported as cargo to the initial sorting compartment ...

RAB7A plays a central role in the final stages of autophagy, facilitating autophagosome-lysosome fusion, lysosome positioning, and cargo degradation. Its activation by guanine nucleotide exchange ...

Researchers from the Babraham Institute, UK, and the German Center for Neurodegenerative Diseases (DZNE) have identified a backup mechanism of protein quality control which prevents the toxic effects ...

Researchers have identified a backup mechanism of protein quality control which prevents the toxic effects of protein aggregation in specific tissues when normal methods of molecular monitoring fail.

Researchers have uncovered a shared brain cell breakdown mechanism behind Alzheimer’s and Parkinson’s diseases, revealing how two different proteins can disrupt neurons in the same devastating way.

Researchers from Harvard Medical School (HMS) have discovered how a protein called midnolin plays a key role in degrading many short-lived nuclear proteins. Their study showed that midnolin acts by ...