Whereas circadian period length in Drosophila melanogaster is directly connected to Per protein phosphorylation and stability 4, the molecular correlate for period length in mammals is not known.

Due to a loss of functionality in hematopoietic stem cells, immune defects occur during aging. Now, researchers have identified gene Per2, whose deletion leads to a stabilization of the number of ...

Researchers find that a key circadian clock controlling kinase, CK1D -- controlling the stability of PER2 -- has two forms, one that stabilizes PER2 and one that destabilizes it. A long-studied factor ...

No significant financial relationships to disclose. This is an ASCO Meeting Abstract from the 2008 ASCO Annual Meeting. This abstract does not include a full text component.

Mice lacking the Period 2 (Per2) gene, a gene associated with circadian rhythm, are considered a potential animal model for studying vulnerability to drug abuse. However, their response towards ...