People who have an inflammatory bowel disease like ulcerative colitis often have problems caused by inflammation in other parts of their bodies. One of these is a skin condition called pyoderma ...

A 2-point improvement in pain based on a numeric rating scale may indicate that patients are responding to treatment for pyoderma gangrenosum. To help determine whether a patient with pyoderma ...

Pyoderma gangrenosum was first described as an extraintestinal manifestation of inflammatory bowel disease (IBD) by Brunsting and colleagues in 1930. 1 They described painful enlarging necrotic ulcers ...

An international team of researchers report in the journal Nature Immunology that a mutation in the gene OTULIN causes pediatric-onset pyoderma gangrenosum, characterized by recurrent ulcerating skin ...

A 59-year-old woman with systemic lupus erythematosus presented with a 1-month history of an enlarging, exquisitely painful ulcer on her left calf (Figure 1). She reported that it had occurred ...

The question Some monogenic inborn errors of immunity (IEI) manifest as severe, early onset inflammatory diseases affecting several tissues and organs 1. The discovery of new IEIs creates ...

Dr. Gott c/o United Media, 200 Madison Ave., 4th fl., New York, NY 10016. DEAR DR. GOTT: I have an open wound on my leg that my surgeon thought was an infection. After eight surgeries, I was ...

InflaRx ( (IFRX)) has shared an announcement. On December 30, 2025, InflaRx reported detailed Phase 3 data analyses for vilobelimab in pyoderma gangrenosum (PG), a rare, difficult-to-treat ulcerative ...

Please provide your email address to receive an email when new articles are posted on . Patients with pyoderma gangrenosum are at greater risk of all-cause and cause-specific mortality compared with ...

A 39-year-old woman with a history of regional enteritis presented with an itchy rash on a tattoo on her left leg that she had received two weeks earlier (Figure 1A). We diagnosed allergic contact ...

A systematic review of 63 cases found that pyoderma gangrenosum (PG) during pregnancy or postpartum was often misdiagnosed, delaying treatment and leading to inappropriate interventions. Researchers ...

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