In mammalian cells, the nucleolus is the central site for ribosome biogenesis. It is composed of distinct subcompartments: the fibrillar center (FC), the dense fibrillar component (DFC), the periphery ...

The discovery of ribosomes dates back to the 1950s, when George Palade first observed dense particles in the cytoplasm of cells using electron microscopy. These particles were later named "ribosomes" ...

Breast cancer is the most common cancer in women. The development of breast cancer often originates from epithelial cells in the mammary gland – the very cells that specialise in milk production ...

Cryo-EM structure of the Giardia ribosome reveals a highly compact, GC-rich rRNA with eukaryotic r-proteins. (A) Structure of the Giardia ribosome with all the r-proteins colored (SSU, shades of blue ...

Breast cancer is the most common cancer in women. The development of breast cancer often originates from epithelial cells in the mammary gland – the very cells that specialize in milk production ...

MYC is a key regulator of RNA Polymerase I (Pol I) transcription, promoting rRNA synthesis both directly and indirectly. MYC overexpression is common in many cancer types, where it drives increased ...

Protein synthesis refers to the process by which cells construct proteins. It's a fundamental cellular mechanism for all ...