When single-molecule super-resolution microscopes were first commercialized some 15 years ago, they made headlines for their ability to resolve individual molecules and structures at the nanometer ...

Super-resolution microscopy has transformed the study of renal podocytes by breaking through the ~250 nm diffraction limit of conventional light microscopy. Podocytes, with their interdigitating foot ...

Single-Molecule Localization Microscopy (SMLM) has traditionally faced challenges to optimize signal-to-noise ratio, penetration depth, field-of-view (FOV), and spatial resolution simultaneously. Here ...

Overcoming the resolution limit in a light microscope of around half a wavelength of light (about 250 nanometers) is one of the most significant developments in optics. Due to the wave nature of light ...

Even those who maintain that super-resolution microscopy is a powerful tool of biological discovery have admitted that it may have a bit of an image problem. For example, in a recent review, several ...

To unravel the complexities of biological phenomena, scientists have long relied on microscopy to visualize the intricate details of their specimens, including tissue architecture, cell morphology, ...

Using patient-derived cells and advanced imaging, researchers showed that RPGR mutations disrupt cilia coordination and ...

In blood cancers such as chronic lymphocytic leukemia, B cells of the immune system multiply uncontrollably. One form of therapy involves labeling the CD20 protein on the surface of the B cells with ...

Researchers at The Hong Kong University of Science and Technology (HKUST) have uncovered how mutations in a specific gene can trigger a rare respiratory disease, shedding light on the critical role ...

Advanced light microscopy techniques are giving scientists a new understanding of human biology and what goes wrong in diseases Katarina Zimmer, Knowable Magazine Key takeaways: Super-resolution ...

When trying to measure molecular structures with nanometer precision, every bit of noise shows up in the data: someone walking past the microscope, tiny vibrations in the building and even the traffic ...

As a researcher interested in the architecture and organization of neurons within mammalian brains, Christophe Leterrier, a neuroscientist at the French National Centre for Scientific Research-Aix ...