Overcoming the resolution limit in a light microscope of around half a wavelength of light (about 250 nanometers) is one of the most significant developments in optics. Due to the wave nature of light ...

Even those who maintain that super-resolution microscopy is a powerful tool of biological discovery have admitted that it may have a bit of an image problem. For example, in a recent review, several ...

Using patient-derived cells and advanced imaging, researchers showed that RPGR mutations disrupt cilia coordination and ...

Researchers at The Hong Kong University of Science and Technology (HKUST) have uncovered how mutations in a specific gene can trigger a rare respiratory disease, shedding light on the critical role ...

Stretching protein samples in all directions pulls molecules farther apart, allowing them to be visualized using only light ...

We present super-resolved coherent anti-Stokes Raman scattering (CARS) microscopy by implementing phase-resolved image scanning microscopy, achieving up to two-fold resolution increase as compared ...

When single-molecule super-resolution microscopes were first commercialized some 15 years ago, they made headlines for their ability to resolve individual molecules and structures at the nanometer ...

To unravel the complexities of biological phenomena, scientists have long relied on microscopy to visualize the intricate details of their specimens, including tissue architecture, cell morphology, ...

In blood cancers such as chronic lymphocytic leukemia, B cells of the immune system multiply uncontrollably. One form of therapy involves labeling the CD20 protein on the surface of the B cells with ...

There is a growing demand for non-invasive insights into the complex three-dimensional subcellular dynamics within living tissues on the frontier of biological research. To achieve simultaneous ...

As a researcher interested in the architecture and organization of neurons within mammalian brains, Christophe Leterrier, a neuroscientist at the French National Centre for Scientific Research-Aix ...