We report on a family with recessive resistance to the action of thyrotropin-releasing hormone (TRH) due to a nonsense homozygous mutation in the TRH receptor (TRHR) gene (p.R17X). We examined the in ...

Regulation of thyroid hormone (TH) levels is a complex multilevel phenomenon. The paraventricular nucleus (PVN) of the hypothalamus (the region of the brain that controls the involuntary nervous ...

Discover how therapeutic peptides act as biological messengers to treat disease, improve metabolism, and enhance immune ...

High TSH levels can mean you have an underactive thyroid or a pituitary gland tumor. Low TSH levels can mean you have an overactive thyroid or issues with the pituitary gland. TSH levels are first ...

Levels of thyroid hormones in serum are tightly regulated by the hypothalamic-pituitary-thyroid axis (Figure 1). Hypothalamic TSH-releasing hormone (TRH) is secreted mainly from the paraventricular ...

The mechanism on how a single hormone manages to trigger two different functions, i.e. seasonal sensing and metabolism, without any cross activity has been identified by researchers. Through an ...

The thyroid gland produces two thyroid hormones, triiodothyronine (T3) and thyroxine (T4), and releases them as needed by the body. The hypothalamus and the pituitary gland help control the thyroid ...

A blood test can check the amount of hormones that your thyroid is making. Many factors can affect these levels. (Photo credit: Jarun011/Dreamstime) A TSH test is done to find out if your thyroid ...