The Monday Night Football game is at the 49ers’ home stadium, the Levi’s Stadium, in Santa Clara. The game will be on ESPN. Most of the upcoming Monday Night Football games will be ESPN exclusive games. Streaming options include ESPN’s new direct-to-consumer streaming platform and NFL+, the NFL’s streaming service.

The Carolina Panthers and the San Francisco 49ers take the field for NFL Monday Night Football tonight in Week 12. MNF start time, schedule and how to watch.

Find out why Xavier Legette anchors our all-wide receiver same-game parlay play for MNF. Free Panthers vs. 49ers SGP picks and NFL wagering advice for November 24, 2025.

The 5-3 San Francisco 49ers hit the road to MetLife Stadium this afternoon for a matchup with the struggling New York Giants. My 49ers vs. Giants predictions and top NFL picks are calling for San Fran to take care of business and cover the number against ...

Panthers vs. 49ers Picks is the kind of keyword you want to read before locking totals — this matchup has volatile offenses, a handful of injury notes that tilt both directions, and weather that won’t kill a passing game.

Get the best Panthers vs. 49ers predictions and odds ahead of their Monday Night Football clash at Levi's Stadium. Free NFL picks for November 24.

With a win tonight, the 49ers’ odds of making the playoffs move from 83 percent from 89 percent in The Athletic’s NFL Playoff Simulator. With the Rams firmly atop the NFC West (and, now, the entire NFC), San Francisco is overwhelmingly likely to make the playoffs as a wild-card team.