The risks of 4 types of skin cancers were investigated among patients who have neurofibromatosis type 1, a multisystem autosomal dominant genetic syndrome characterized by loss of neurofibromin. Basal ...

Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive sarcomas that arise from benign plexiform neurofibroma (PN) and borderline atypical neurofibroma (AN) in the setting of ...

Neurofibromatosis type 1 (NF1) is a genetic condition that causes tumors to grow along nerves in the skin, brain, and other parts of the body. These tumors are usually noncancerous (benign), but they ...

Neurofibromatosis type 1 (NF1) is a multisystem genetic disorder arising from mutations in the NF1 gene that encodes the tumour suppressor protein neurofibromin. Research has increasingly refined our ...

PHILADELPHIA (WPVI) -- There's no cure for neurofibromatosis (NF), and it's been said that the rare genetic disorder is becoming more common. Now a local mother, who was born with the rare disease, is ...

Researchers identify bone-forming cells as the driver of scoliosis caused by a genetic disorder, which can be prevented ...

The FDA has approved selumetinib (Koselugo, AstraZeneca) for adults with neurofibromatosis type 1 (NF1) who have symptomatic, inoperable plexiform neurofibromas (PN). With the new regulatory decision, ...

Almost half of adults and children with neurofibromatosis type 1 (NF1) responded to the investigational MEK inhibitor mirdametinib, a large multicenter study of the rare condition showed. Overall, 53 ...

Sequences of 529 cancer driver genes were analyzed in 6,381 tumors, yielding 391 NF1-mutated tumors in which NF1 LOH analysis was performed. Driver genes were evaluated by tumor type including ...

Because NF1 is an unpredictable disorder, it varies widely in severity – even among two people in the same family. Some people with NF1 may be completely unaware that they are affected, experiencing ...

A Pennsylvania mother and her one-year-old son share an unusual bond. They are both living with the same rare genetic disease. Lindsey Marson, 28, and her son, Bryson, were both born with ...