Transfer RNAs (tRNAs) deliver specific amino acids to ribosomes during translation of messenger RNA into proteins. The abundance of tRNAs can therefore have a profound impact on cell physiology, but ...

Blacksburg, Va. – Scientists at the Virginia Bioinformatics Institute (VBI) report in the Journal of Bacteriology that two alphaproteobacteria lack the universal extra guanylate nucleotide typically ...

For disorders driven by a known genetic component, research understandably focuses on developing a drug targeting that genetic signature. When that works, the outcome benefits patients but the end ...

A new advanced, high-throughput sequencing technique should enable scientists to have a firmer grasp on the activity of naturally occurring microbiomes in response to real-world conditions and diet.

In-depth mass spectrometric analysis reveals how cells survive stress by coordinating various enzymes that modify RNAs involved in protein synthesis. Despite the remarkable functional diversity that ...

We welcome Drs Nathan Howell and Boaz Tirosh as new faculty members in the Department of Biochemistry! Dr. Howell is an Assistant Professor with research interests in tRNA modification. He is an ...

Two new options for making designer proteins made news in 2001—both from labs at Scripps Research Institute. Since 2001, Schimmel and Schultz have taken different directions with unnatural amino acids ...

When studying for a doctoral degree (PhD), candidates submit a thesis that provides a critical review of the current state of knowledge of the thesis subject as well as the student’s own contributions ...

A cell contains several hundred thousand tRNA molecules, each of which consists of only 70 to 90 nucleotides folded into a cloverleaf-like pattern. At one end, tRNAs carry one of the twenty amino ...

Scientists at the Virginia Bioinformatics Institute (VBI) report that two alphaproteobacteria lack the universal extra guanylate nucleotide typically found in the transfer RNA molecule tRNAHis. tRNAs ...