Despite modern high-throughput sequencing, the genetic cause of most rare movement disorders remains unclear. A research team ...

Since she was born 20 years ago, Sylva Eugenie Davis of Kansas City has not been able to use her arms or legs. The nerve tracts in the neck region of her spinal cord were injured at birth, causing ...

An immune-related gene has now been tied to a rare inherited neurological disorder, revealing an overlooked pathway in the ...

Mutations in 3 genes (SPG4, SPG3, and SPG31) are implicated in one half of the autosomal dominant hereditary spastic paraplegias, which are part of the larger group of hereditary spastic diplegias ...

Patients with spastic paraplegia type 15 develop movement disorders during adolescence that may ultimately require the use of a wheelchair. In the early stages of this rare hereditary disease the ...

Despite modern high-throughput sequencing, the genetic cause of most rare movement disorders remains unclear. A research team ...

Mike Wolanin | The Republic Kyle Alumbaugh demonstrates how he uses his wheelchair ramp participate in 5k run, walk or roll to raise awareness for Hereditary Spastic Paraplegia and Primary Lateral ...

Hereditary spastic paraplegia (HSP), also known as familial spastic paraparesis, is a term used for a group of inherited diseases that affect the upper motor neurons traveling from the brain through ...

Spastic paraplegia (SP) in hereditary form is a genetically and clinically heterogeneous group of diseases with distinctive features of axonal degeneration in corticospinal tracts. Progressive ...

(Philadelphia, PA) – While it might have given our ancestors an evolutionary advantage, an "unstable" region on human chromosome 15 is also the source of a set of inherited neurological diseases.