Texans head coach DeMeco Ryans is a former 49ers defensive coordinator under Kyle Shanahan, so San Francisco knows how ...

Kickoff from NRG Stadium is set for 1 p.m. ET, and the Texans are 2.5-point favorites, according to the latest 49ers vs.

San Francisco 49ers quarterback Mac Jones locates tight end George Kittle for a 17-yard sliding grab against the Houston ...

San Francisco 49ers wide receiver Jauan Jennings can't hold on to a deep pass attempt from quarterback Mac Jones against the ...

The redemption arc of quarterback Mac Jones was fun while it lasted, but the San Francisco 49ers need starting QB Brock Purdy ...

The 49ers just lost 26-15 to the Houston Texans, who came into the game with just two wins and four losses. Now, the 49ers ...

San Francisco 49ers TE George Kittle and QB Mac Jones showcased flashes of playmaking during the loss to Houston, highlighted ...

San Francisco 49ers QB Mac Jones fired a strike to WR Kendrick Bourne, moving the chains with an 18-yard gain vs. the Texans.

A week after the 49ers earned a 20-10 prime-time home win over the Atlanta Falcons, the Niners’ shorthanded defense was on ...

The San Francisco 49ers dropped their third game of the season on Sunday, falling short 26-15 on the road to the Houston ...