Christian McCaffrey speaks out on the San Francisco 49ers’ mounting injury challenges after losing to the Houston Texans.

In Houston’s second offensive drive, rookie running back Woody Marks made another highlight-reel play. On second & 5, ...

The Houston Texans jumped on the San Francisco 49ers early in an impressive bounce-back performance Sunday at NRG Stadium in ...

Philadelphia Eagles running back Tank Bigsby caps off his day with a 16-yard run through multiple New York Giants tacklers.

San Francisco 49ers running back Christian McCaffrey hits a brutal juke on a 27-yard catch and run against the Houston Texans ...

The Texans arguably played one of their better games of the season and Houston's Week 8 report card reflects that.

San Francisco 49ers CB Deommodore Lenoir picked off Houston Texans QB C.J. Stroud, marking the team's first interception of ...

San Francisco 49ers TE George Kittle made a strong grab in the end zone for a 17-yard touchdown against the Houston Texans.

The Texans have dominated the 49ers, outgaining them 230 to 25 and outscoring them 13-0. The Texans have 10 first downs to ...

McCaffrey rushed eight times for 25 yards and brought in three of six targets for 43 yards in the 49ers ' 26-15 loss to the Texans on Sunday.

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Our expert Week 8 NFL predictions expect the 49ers to cover the spread behind All-Pro running back Christian McCaffrey!