Anthony Santander hit a game-ending, two-run homer with two outs in the ninth inning, and the Baltimore Orioles moved closer to a postseason berth with a 5-3 victory over the San Francisco Giants.

Anthony Santander hit a two-run home run in the bottom of the ninth Thursday, giving the Orioles a much-needed 5-3 win.

Santander’s shot off Ryan Walker (9-4) came after Casey Schmitt tied the game at 3-all with a single off Seranthony Domínguez in the top of the ninth.

Mike Yastrzemski homered on the game’s first pitch, Michael Conforto also hit a solo shot and the San Francisco Giants beat the sinking Baltimore Orioles 5-3.

Juan Soto, held out of the starting lineup because of a bruised knee, lined a pinch-hit double in the middle of a three-run, 10th-inning uprising as the New York Yankees outlasted the host Oakland Athletics 4-2 in the opener of a three-game series on Friday.

Less than three hours before first pitch Thursday, a large group of Yankees arrived in the visiting clubhouse that still had a stench of cheap champagne and beer from the night before. The Yankees had secured the American League’s first playoff berth on Wednesday night,