By Alexander Cornwell, Parisa Hafezi and Jeff MasonTEL AVIV/DUBAI/WASHINGTON (Reuters) - Israel and Iran kept up their attacks, killing and wounding civilians and raising concern among world leaders at a G7 meeting in Canada this week that the biggest battle between the two old enemies could lead to a broader regional conflict.

Israel said Iran had fired over 270 missiles since Friday, 22 of which slipped through the country’s sophisticated multi-tiered air defenses and caused havoc in residential suburbs, killing 14 people and wounding 390 others as of late Sunday.

Israel and Iran have traded more missile attacks despite international calls for a halt to the fighting, with neither country showing signs of backing down as the conflict between the regional foes raged for a third day.

The retaliatory strikes came on Saturday, a day after Israel killed top Iranian military leaders and scientists and destroyed an aboveground nuclear enrichment plant near Natanz.

The conflict between Israel and Iran continues on Day 4 (Monday) with both sides launching a barrage of drones and missiles at military and residential sites. Tehran reportedly struck close to Haifa port in Israel,

Israel and Iran have traded missile strikes for a third straight day. Israel on Sunday hit targets in Tehran including the Defense Ministry and sites it claims are tied to Iran’s nuclear program.

President Donald Trump told ABC News that "it's possible we could get involved" in the ongoing conflict between Israel and Iran. The president made the comments to ABC News' Rachel Scott. He also reiterated that the U.S. is "not at this moment involved" in the conflict.

President Trump rejected an Israeli plan in recent days to kill Iran's Supreme Leader Ayatollah Ali Khamenei, a senior U.S. official told USA TODAY.