心肌细胞（CM）是不可再生的。 自我更新的多能人类胚胎干细胞 (hESC) 可以分化为用于细胞疗法的 CM。 在成人CM中，Ca (2+)诱导的Ca (2+)通过兰尼碱受体 (RyR)从肌浆网 (SR)释放是兴奋-收缩耦合的关键。 因此，hESC 衍生的 CM 需要具有适当的 Ca (2+) 处理特性，才能与受体心脏成功进行功能整合。 在这里 ...

心肌细胞（CM）是不可再生的。 自我更新的多能人类胚胎干细胞 (hESC) 可以分化为用于细胞疗法的 CM。 我们最近报道，Ca (2+) 处理对于 hESC 衍生的 CM (hESC-CM) 的兴奋-收缩耦合至关重要，具有功能性但不成熟。 胞质Ca (2+)瞬时幅度较小、动力学较慢和肌浆网 (SR)Ca (2+)含量减少等不成熟特性可归因于特定Ca ...

Research Objective Approximately 20,000 babies are born annually with kidney disease; the long-term outcome is poor. These studies address new ways to develop mini-kidney structures for ...

Traumatic brain injuries (TBI) are the seventh leading cause of disability globally with 48.99 million prevalent cases and 7.08 million years lived with diability. Approximately 80 % of TBI patients ...

Pursuant to Executive Order N-29-20, certain provisions of the Bagley-Keene Open Meeting Act are suspended due to a State of Emergency in response to the COVID-19 pandemic. Consistent with the ...

干细胞机构主席 Alan Trounson 博士表示：“获得来自多种复杂疾病的高保真 iPSC 系将成为研究的重要加速器。” “这一举措将为科学家提供多种细胞系，这些细胞系应该具有代表任何人类疾病（如阿尔茨海默病、心脏病、肺纤维化和自闭症）多样性的遗传变异。 科学家和公司可以利用这些细胞以一种 ...

Up to 12,000 Americans suffer a spinal cord injury (SCI) each year. This condition leads to a high level of permanent disability and decreased life expectancy. Currently, there are no… ...

Quest – Discovery Stage Research Projects University of California, Berkeley Scalable, Defined Production of Oligodendrocyte Precursor Cells to Treat Neural Disease and Injury $1,627,099 Tools and ...

La maladie coronarienne, entraînant un blocage du flux sanguin vers le cœur, est une cause majeure de crise cardiaque. L'âge et les blessures provoquent des changements structurels et fonctionnels ...

Research Objective We will identify SAR-CoV-2 T cell epitopes for vaccine development and specific TCRs for adoptive T cell therapy using a stem cell-based platform to generate specialized dendritic ...

Nos entristece profundamente saber del fallecimiento de un paciente que participaba en el ensayo clínico de fase 2 de Rocket Pharmaceuticals con RP-A501 para tratar la enfermedad de Danon. En nombre ...

CIRM was established in 2004 with the passage of Proposition 71, the California Stem Cell Research and Cures Initiative. The statewide ballot measure, which provided $3 billion in funding for stem ...