Loop vs Thiazide Diuretics - Key Differences for Your Practice! Understanding the nuances between loop and thiazide diuretics is crucial for optimal patient management, especially when considering electrolyte imbalances and renal function. Here’s a quick recap of their key differentiators: ➡️ Common ground: Both can lead to hyperuricemia. ⚖️ Calcium Balance: * Loop Diuretics: Cause increased urinary calcium excretion, leading to hypocalcemia. Mnemonic: Loop Loses Calcium! 📉 * Thiazide Diuretics