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How does folate actually get into the brain? John Slattery explains it with a docking picture. The folate receptor on the blood-brain barrier is the docking site. Folate has to lock onto it to be carried across. When an autoantibody binds to that receptor first, folate cannot dock, and less of it reaches the brain. That is the mechanism behind a result that confuses a lot of families: blood folate reads normal, brain folate can still be low. One receptor. One dock. One antibody in the way. Once
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